NMR-based identification of the major bioactive molecules from an Italian cultivar of Lycium barbarum

NMR-based identification of the major bioactive molecules from an Italian cultivar of Lycium barbarum

Highlights
• Specialised products from an Italian Lycium barbarum cultivar were determined.
• The phytochemical analysis of the different plant parts was conducted.
• A unique phytochemical profile of an Italian L. barbarum cultivar was determined.
• Among others known metabolites, two unreported natural products were identified.


Abstract
Lycium barbarum (Solanaceae), long known to the traditional Chinese medicine because of its many health-promoting effects, has of late spread widely across the Western hemisphere, mainly on account of the nutritional richness in vitamins, minerals and antioxidant metabolites of its fruits. Data on bioactive metabolites from fruits and leaves, which are commonly consumed in soups and salads, are scarce and sometimes even contradictory. By means of NMR, the present study identified the specialised products contained in an Italian cultivar of L. barbarum. Kaempeferol, caffeic acid, 3,4,5-trihydroxycinnamic acid and 5-hydroxyferulic acid were found in fresh fruits; rutin and chlorogenic acid were detected in leaves and flowers; also, a previously undescribed N,N-dicaffeoylspermidine derivative was identified in flowers, while N-feruloyltyramine derivatives, for which interesting anti-inflammatory properties have been reported, turned out to be the major bioactive molecules in stems. The plethora of the detected bioactive molecules amplifies the nutraceutical value of berries and leaves and prompts the exploitation of L. barbarum flowers and pruned stems as sources of beneficial compounds.
Graphical abstract
An Italian cultivar of L. barbarum was fully analysed by NMR. The detected bioactive molecules defined a quite unique phytochemical profile of berries, leaves, flowers and stems, thus amplifying the nutraceutical value of the Italian product and prompting the exploitation of the inedible parts of the plant for the obtainment of precious health-promoting metabolites.

Author information
1 Department of Pharmacy, University of Napoli "Federico II", via D. Montesano, 49, 80131, Napoli, Italy.
2 "LYKION" for the "GOJI ITALIANO", Via Nazionale, 668, 89018, Villa San Giovanni, RC, Italy.
3 Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller- University, Philosophenweg 14, D-07743, Jena, Germany.
4 Via S. D'Acquisto, 31, 87032, Amantea, CS, Italy.
5 Department of Pharmacy, University of Napoli "Federico II", via D. Montesano, 49, 80131, Napoli, Italy. Electronic address: forino@unina.it.

Full text links
  1. Qixiang is a wolfberry products processing manufucturer with 12,800 ha of organic wolfberry plantation. The current products of Qixiang Company are Goji Berry Juice, Clarified Goji Berry Juice, Organic Dried Goji Berry, Goji Berry Juice Concentrate, Goji Berry Powder, Goji Polysaccharide, Goji Seed Oil, Goji Berry Juice Drinks and other products(in 5 classes of Goods, about 20 specifications). If you need to customize or purchase, please give us a message, we will reply to you within 24 hours.

Click image to refresh